Thermo Fisher Scientific Phospho-Histone H3 (Ser10) Monoclonal Antibody (3HH3-4C8)
인간 시료에서 Ser10 위치의 히스톤 H3 인산화를 검출하는 단클론 항체. Western blot에 최적화되어 있으며, 고특이성과 재현성이 우수함. Ovalbumin 결합 합성 펩타이드 면역원 사용. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3HH3-4C8 |
| Immunogen | Ovalbumin conjugated synthetic peptide (ARK[phospho-S]TGGKAPRKQLC) corresponding to aa 7–20 of histone H3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2633019 |
Product Specific Information
MA3-057 detects phosphorylated histone H3 at Ser10 in human samples and has been successfully used in western blot applications.
The MA3-057 immunogen is a synthetic peptide conjugated to ovalbumin corresponding to residues 7–20 of Human Histone H3, which is highly conserved across multiple species.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. Together with four core histone proteins, it binds to DNA forming the nucleosome structure. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability.
Post-translational modifications of histones directly alter chromatin structure or enable transcription factor binding. The N-terminal tail of histone H3 can undergo various modifications such as methylation, acetylation, and phosphorylation, influencing key cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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