Thermo Fisher Scientific Phospho-Histone H3 (Ser10) Monoclonal Antibody (3HH3-4C8)

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

MA3-057 detects phosphorylated histone H3 at Ser10 in human samples and has been successfully used in western blot applications.
The MA3-057 immunogen is a synthetic peptide conjugated to ovalbumin corresponding to residues 7–20 of Human Histone H3, which is highly conserved across multiple species.

Target Information

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. Together with four core histone proteins, it binds to DNA forming the nucleosome structure. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability.
Post-translational modifications of histones directly alter chromatin structure or enable transcription factor binding. The N-terminal tail of histone H3 can undergo various modifications such as methylation, acetylation, and phosphorylation, influencing key cellular processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.