Thermo Fisher Scientific SKA1 Polyclonal Antibody
Human SKA1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P), ICC/IF, Competition Assay에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 세포분열 중 키네토코어-미세소관 결합 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
| Competition Assay (CA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SKA1. Recombinant protein control fragment (Product #RP-98240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647324 |
Product Specific Information
Immunogen sequence:
ELLNKLELEI QYQEQTNNSL KELCESLEED YKDIEHLKEN IPSHLPQVTV TQSCVKGSDL DPEEPIKVEE PEPVKKPPKE QRSIKEM
Antigen sequence identity:
- Mouse: 70%
- Rat: 76%
Target Information
During mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, enabling segregation of paired chromosomes. Kinetochores (KT) on centromeric chromatin are essential for proper chromosome-spindle attachment.
The spindle and kinetochore complex (SKA), composed of SKA1, SKA2, and SKA3, is crucial for stable KT-MT interactions and timely anaphase onset.
Depletion of SKA1 or SKA2 by siRNA causes loss of both proteins from the KT without affecting overall KT structure. Cells lacking the SKA complex experience prolonged metaphase-like delay, underscoring its role in spindle checkpoint silencing and metaphase plate maintenance.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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