Thermo Fisher Scientific BTBD12 Polyclonal Antibody
Human BTBD12 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000–1:2,500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. DNA 손상 복구 관련 연구에 적합.
- 카탈로그번호
- PA564270
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BTBD12 (UniProt ID: Q8IY92-1, antigen range: 717–812) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638617 |
Product Specific Information
Immunogen sequence:
LIQYVNNEGF SAVEDGVLTQ RVLLGDVSTE AARTFLHYLY TADTGLPPGL SSELSSLAHR FGVSELVHLC EQVPIATDSE GKPWEEKEAE NCESRA
Sequence identity with orthologs:
- Mouse: 65%
- Rat: 69%
Target Information
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and forms a multiprotein complex with ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases. It also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), protein kinase PLK1, and C20orf94.
This multiprotein complex is essential for repair of specific DNA lesions and for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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