Thermo Fisher Scientific BMPR1A Polyclonal Antibody

Thermo Fisher Scientific BMPR1A Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (99%), Rat (98%), Xenopus laevis (89%), Dog (99%), Pig (100%), Chicken (95%), Sheep (99%), Rhesus Monkey (100%), Bovine (98%).
• Positive control: human BMPR1A-transfected 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily.
TGF-betas and activins transduce their signals through heteromeric complexes with two types of serine/threonine kinase receptors:

• Type I receptors: ~50–55 kD
• Type II receptors: ~70–80 kD

Type II receptors bind ligands independently but require type I receptors for signaling, whereas type I receptors need type II receptors for ligand binding.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.