Thermo Fisher Scientific Phospho-XRCC1 (Ser485, Thr488) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:2,000–1:10,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:2,000–1:10,000

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Predicted to react with Rat (based on 100% sequence identity)

Target Information

XRCC1 (X-ray cross complementing factor-1)은 DNA base excision repair에 관여하는 단백질입니다.
XRCC1은 70 kDa 크기의 단백질로, poly(ADP-ribose) polymerase (PARP), DNA Ligase III, DNA polymerase beta 등과 물리적으로 결합하는 것으로 알려져 있습니다.
또한 XRCC1은 BRCT 도메인을 포함하며, 이는 BRCA1 단백질의 C-말단 영역에서 처음 발견되었습니다.
BRCT 도메인은 XRCC1과 DNA ligase III-alpha 간의 단백질-단백질 상호작용을 매개합니다.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.