Thermo Fisher Scientific SPHK2 Polyclonal Antibody
SPHK2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성, 액상 형태, -20°C 보관. SPHK2 관련 세포 신호 연구에 적합.
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SPHK2 (Accession Q9NRA0), corresponding to amino acid residues G56–R106 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818653 |
Product Specific Information
Antibody detects endogenous levels of total SPHK2.
Target Information
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a key signaling molecule. S1P acts through G-protein coupled receptors to regulate diverse cellular processes such as differentiation, apoptosis, calcium mobilization, and cell motility. SPHK2 plays roles in cardiogenesis, vascular maturation, immune cell trafficking, and neuronal system regulation. Inhibitors of SPHKs are being explored as potential cancer therapeutics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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