Thermo Fisher Scientific Apolipoprotein L3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MDSEKKRFTE EATKYFRERV SPVHLQILLT NNEAWKRFVT AAELPRDEAD ALYEALKKLR TYAAIEDEYV QQKDEQFREW FLKEFPQVKR KIQESIEKLR ALANGIEEVH RGCTISNVVS SSTGAASGIM SLAGLVLAPF TAGTSLALTA AGVGLGAASA VTGITTSIVE HSYTSSAEAE ASRLTATSID RLKVFKEVMR DITPNLLSLL NNYYEATQTI GSEIRAIRQA RARARLPVTT WRISAGSGGQ AERTIAGTTR AVSRGARILS ATTSGIFLAL DVVNLVYESK HLHEGAKSAS AEELRRQAQE LEENLMELTQ IYQRLNPCHT H

Positive Samples: DU145, A-549, BxPC-3, Mouse kidney
Cellular Location: Cytoplasm

Target Information

Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein L gene family encodes six highly homologous proteins designated apoL1–6, which are associated with large high-density type lipoproteins (HDL). The human apoL family maps to chromosome 22q12.1–13.1 within a 127,000 bp region.

apoL2 and apoL3 may allow the binding of lipids to organelles or may be involved in the movement of lipids in the cytoplasm. apoL2 localizes to the cytoplasm and is widely expressed, with the highest levels observed in the lung, thymus, pancreas, placenta, adult brain, and prostate. The apoL2 protein is also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis, and fetal brain and liver.

apoL3 also localizes to the cytoplasm and is widely expressed, with highest levels detected in the prostate, lung, and placenta. It is also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea, and mammary gland. Lower levels of apoL3 are observed in the brain, heart, fetal liver, pancreas, and testis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.