Thermo Fisher Scientific CD8 Polyclonal Antibody
Thermo Fisher Scientific의 CD8 Polyclonal Antibody는 마우스 CD8 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공됩니다. 연구용으로 T세포 활성화 및 면역 반응 분석에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within mouse CD8 aa 21–70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802660 |
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules. CD8α also forms homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Binding of MHC-I/peptide complexes by antigen-presenting cells triggers Lck recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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