Thermo Fisher Scientific Metabotropic glutamate receptor 2 Polyclonal Antibody
Metabotropic glutamate receptor 2 (mGluR2)에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A 정제, 고순도 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GRM2, amino acids 801–872 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors involved in fast excitatory synaptic transmission. Additionally, glutamate regulates enzymes producing second messengers via G-protein-coupled receptors, known as metabotropic glutamate receptors (mGluRs).
Group-I receptors (mGluR1a, mGluR5) stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
Group-II (mGluR2, mGluR3) and Group-III receptors inhibit adenylyl cyclase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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