Thermo Fisher Scientific SMC5 Polyclonal Antibody
SMC5 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. DNA 이중가닥 절단 복구 및 염색체 응집 연구에 활용. 4°C 보관, 1 mg/mL 농도의 액상 형태. 연구용 전용 제품.
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- A300236AM
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1050 and the C-terminus (residue 1101) of Human Structural Maintenance of Chromosomes 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Core component of the SMC5-SMC6 complex, involved in the repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. It is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components, leading to shelterin complex disassembly in ALT-associated PML bodies (APBs). Also required for recruitment of telomeres to PML nuclear bodies and for sister chromatid cohesion during prometaphase and mitotic progression, independent of SMC6. The SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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