Thermo Fisher Scientific p53 Monoclonal Antibody (OTI2H6), TrueMAB

Applications

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 upregulates transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 consists of an N-terminal transactivation domain, central DNA-binding domain, oligomerization domain, and C-terminal regulatory domain.

Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and functions as a tumor suppressor. It is also linked to aging, oxidative stress, and learning/memory deficits. Expression levels are low in normal cells but high in transformed cell lines, contributing to malignancy. Mutations in TP53 disrupt DNA binding and tumor suppression, occurring in both somatic and germline forms, such as in Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.