Thermo Fisher Scientific ROS1 Monoclonal Antibody (OTI1A1), TrueMAB
ROS1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western Blot, IHC, ICC/IF에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 기반 보존액. Human ROS1(aa 1882-2125) 항원으로 제작된 연구용 시약입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1882–2125 of human ROS1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases transfer a phosphate group from ATP to substrate proteins, mediating signal transduction in eukaryotic cells. They regulate metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family includes more than 500 gene products and is classified into 8 major groups based on catalytic domain sequence comparisons. The tyrosine kinase (TK) group primarily regulates cell-cell interactions such as differentiation, adhesion, motility, and death. Approximately 90 TK genes have been sequenced—58 receptor TKs (e.g., EGFR, EPH, FGFR, PDGFR, TRK, VEGFR) and 32 cytosolic TKs (e.g., ABL, FAK, JAK, SRC).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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