Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Rabbit polyclonal antibody against human Nurr1 (NR4A2) for ICC/IF applications. Recognizes multiple species including mouse, rat, pig, and bovine. Purified by antigen affinity chromatography, supplied as liquid form. Suitable for research use only.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Nurr1 (proprietary sequence) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2736269 |
Product Specific Information
- Positive Control: Target recombinant protein
- Predicted Reactivity: Mouse (100%), Rat (100%), Pig (100%), Rhesus Monkey (100%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans. NURR1 belongs to the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain. Mutations in this gene have been associated with dopaminergic dysfunction disorders such as Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis. Four transcript variants encoding distinct isoforms have been identified, with additional splice variants possible.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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