Thermo Fisher Scientific TJP3/ZO-3 Polyclonal Antibody
Rabbit polyclonal antibody against TJP3/ZO-3 for WB and IP applications. Unconjugated liquid form, 1 mg/mL concentration. Predicted reactivity with mouse and dog. Suitable for research use only.
- 카탈로그번호
- A304926A
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 883 and 933 of human ZO-3 (UniProt ID: O95049-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Dog
Target Information
ZO-3 (TJP3) is a member of the membrane-associated guanylate kinase (MAGUK) family and functions as a tight junction-associated protein.
Tight junctions form intercellular boundaries between epithelial and endothelial cells. ZO-3 contributes to both structural and signaling functions and contains PDZ, SH3, and GuK domains.
ZO-1 forms complexes with ZO-2 or ZO-3, and these proteins interact with claudin, occludin, and F-actin to link tight junctions with the actin cytoskeleton.
ZO-1 expression is reduced in many breast cancer cell lines. ZO-2 and ZO-3 are ubiquitously expressed in epithelial tight junctions, while ZO-2 is not expressed in non-epithelial tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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