Thermo Fisher Scientific Phospho-FANCD2 (Thr691) Polyclonal Antibody
인간 FANCD2 단백질 Thr691 인산화 부위에 특이적인 폴리클로날 항체입니다. Western blot 및 면역세포염색에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 액상 형태로 -20°C 보관하며 연구용으로 적합합니다.
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- PA5118776
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Thermo Fisher Scientific Phospho-FANCD2 (Thr691) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FANCD2 around the phosphorylation site of Thr691. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903276 |
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, a disorder affecting all bone marrow elements and resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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