Thermo Fisher Scientific HLA-DQB2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total HLA-DQB2.

Target Information

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
Polymorphisms in the alpha and beta chains specify peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However, HLA-DQB2 is not routinely typed, as it is not thought to affect transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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