Thermo Fisher Scientific SPIN2 Polyclonal Antibody
Thermo Fisher Scientific의 SPIN2 폴리클로날 항체는 Human, Mouse, Rat에 반응하며 Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 비결합형 액체 형태이며 안정적인 장기 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human SPIN2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2719945 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
Human SPIN2 expressed by two IL3-dependent murine myeloid cell lines showed moderate antiapoptotic activity after IL3 removal but did not block apoptosis induced by doxorubicin. SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. SPIN2 also did not counteract Fas ligand-induced apoptosis in Jurkat human T cells. Deletion of the C-terminal amino acids of SPIN2 reduced its antiapoptotic activity. In murine myeloid cells, SPIN2 overexpression slowed cell growth and increased the percentage of cells in G2/M phase, especially following IL3 withdrawal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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