Thermo Fisher Scientific CCDC98 Polyclonal Antibody
CCDC98 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. BRCA1 관련 DNA 손상 반응 연구에 적합. 고순도 Protein A 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CCDC98 (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCDC98, also known as Abraxas 1, is identified through protein binding studies using BRCA1 as the target.
It recruits RAP80, a ubiquitin-binding protein, to BRCA1, enabling BRCA1 foci formation in response to DNA damage caused by ionizing radiation.
Both CCDC98 and RAP80 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of either protein show increased sensitivity to ionizing radiation, though less than BRCA1-depleted cells.
This suggests that CCDC98 and RAP80 mediate part of BRCA1’s DNA damage response.
At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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