Thermo Fisher Scientific TRAF3 Polyclonal Antibody
TRAF3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human TRAF3의 N-말단(aa 1-100) 서열 기반 합성 펩타이드로 면역생성되었습니다. 액상 형태이며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human TRAF3 (NP_003291.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.19 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804216 |
Product Specific Information
- Immunogen sequence:
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV - Positive Samples: Mouse brain, Rat brain
- Cellular Location: Cytoplasm, Endosome, Mitochondrion
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins such as TNF receptor associated factors (TRAFs). TRAFs are a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Six TRAFs (TRAF1–TRAF6) have been identified. TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region similar to TNF-alpha receptor-associated factors. TRAF3 binds a single site containing the PEQET sequence, whereas TRAF1 and TRAF2 can bind both PEQET and an additional downstream domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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