Thermo Fisher Scientific TRAF3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Product Specifications

Product Specific Information

• Immunogen sequence:
  MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
• Positive Samples: Mouse brain, Rat brain
• Cellular Location: Cytoplasm, Endosome, Mitochondrion

Target Information

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins such as TNF receptor associated factors (TRAFs). TRAFs are a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Six TRAFs (TRAF1–TRAF6) have been identified. TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region similar to TNF-alpha receptor-associated factors. TRAF3 binds a single site containing the PEQET sequence, whereas TRAF1 and TRAF2 can bind both PEQET and an additional downstream domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.