Thermo Fisher Scientific FOXP3 Monoclonal Antibody (OTI3H2), TrueMAB
FOXP3 단백질을 표적으로 하는 마우스 단클론 항체로, 인간·마우스·랫트에 반응합니다. Western blot에 최적화되어 있으며, 무보존제 PBS 용액 형태로 제공됩니다. 면역조절 연구 및 T세포 기능 분석에 적합합니다.
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Thermo Fisher Scientific FOXP3 Monoclonal Antibody (OTI3H2), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H2 |
| Immunogen | Full length human recombinant FOXP3 protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
FOXP3 (Forkhead box protein 3) is a transcriptional regulator essential for immune homeostasis. It is stably expressed in CD25⁺ CD4⁺ regulatory T cells, at low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 defects cause scurfy phenotype in mice and IPEX syndrome in humans. Expression of FOXP3 in human breast and colon cancer cells is regulated by p53 in response to DNA damage.
Transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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