Thermo Fisher Scientific Human NTRK2 (TRKB), His Tag Recombinant Protein

Thermo Fisher Scientific Human NTRK2 (TRKB), His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots below 20 µL are not recommended.
• Do not store kinase diluted.
• If properly stored at -80°C, product is guaranteed for 6 months from purchase date.
• Protein Form: Cytoplasmic

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family central to the development and maintenance of the mammalian nervous system. It acts as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate short-term synaptic functions and long-term potentiation of brain synapses. TrkB is a tyrosine kinase gene expressed mainly in the central and peripheral nervous systems. Binding of neurotrophins induces phosphorylation of TrkB and downstream MAPK signaling, leading to cell differentiation. Mutations in TrkB are associated with obesity and mood disorders. Multiple splice variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.