Thermo Fisher Scientific AXL Monoclonal Antibody (10E7.1D2)
인간 AXL 단백질을 표적으로 하는 mouse IgG1 단일클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 완충액에 안정화제와 sodium azide를 포함합니다. 세포막 위치 검출 및 암 연구용으로 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10E7.1D2 |
| Immunogen | A recombinant protein of human AXL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Acute myeloid leukemia
- Cellular location: Membrane
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as GAS6. It is involved in cell proliferation and apoptotic cell clearance via TAM receptors. Mice lacking TAM receptors show degenerative and autoimmune phenotypes similar to systemic lupus erythematosus.
AXL may serve as an entry receptor for filoviruses and is used to identify Siglec 6+/Axl+ dendritic cells. Expression of AXL can be upregulated by TLR ligands (e.g., LPS, poly I:C). Soluble AXL, generated by proteolytic cleavage, may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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