Thermo Fisher Scientific CRALBP Monoclonal Antibody (B2)
CRALBP 단백질 검출용 Thermo Fisher Scientific의 B2 단클론 항체. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 생쥐, 흰쥐 등에서 반응하며 RPE 및 Müller 세포 마커로 활용. 단백질 A 정제, PBS/BSA 용액 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.02 µg/mL | 5 publications |
| Immunohistochemistry (IHC) | – | 14 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1 µg/mL | – |
| Immunocytochemistry (ICC/IF) | – | 9 publications |
| Flow Cytometry (Flow) | Assay-dependent | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | – |
| Miscellaneous PubMed (Misc) | – | 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B2 |
| Immunogen | Human recombinant CRALBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2178528 |
Product Specific Information
MA1-813 detects CRALBP protein in bovine, human, mouse, non-human primate, and rat samples.
It has been validated for Western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence applications.
By Western blot, this antibody detects a 37 kDa protein corresponding to human recombinant CRALBP.
The immunogen used for MA1-813 is purified human recombinant CRALBP.
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays a key role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin.
After photoisomerization in the rod outer segment, 11-cis-retinal converts to all-trans-retinal and then to all-trans-retinol, which diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and oxidized into 11-cis-retinal—both processes involving CRALBP.
Mutations causing CRALBP dysfunction are associated with visual diseases such as Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy.
CRALBP is a known marker for RPE and Müller glial cells of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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