Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Calsenilin/KCNIP3.

Target Information

Voltage-gated potassium (Kv) channels play a critical role in potassium currents in the heart and central nervous system. In cardiac tissue, Kv4 channels participate in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.

KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels and modulate their function. There are three known KChIPs:

• KChIP1: Expressed in the brain
• KChIP2: Expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3 (Calsenilin/DREAM): Expressed in brain and testis

KChIP3 not only modulates Kv4 currents but also acts as a transcriptional regulator by binding to DRE (downstream regulatory elements) and repressing transcription of early-response genes such as c-fos. It is also associated with presenilins and implicated in β-amyloid formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.