Thermo Fisher Scientific KChIP3 Polyclonal Antibody
KChIP3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 시료 반응성. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNIP3 (Accession Q9Y2W7), corresponding to amino acid residues R39–T89 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899572 |
Product Specific Information
This antibody detects endogenous levels of total Calsenilin/KCNIP3.
Target Information
Voltage-gated potassium (Kv) channels play a critical role in potassium currents in the heart and central nervous system. In cardiac tissue, Kv4 channels participate in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels and modulate their function. There are three known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (three isoforms: a, b, c)
- KChIP3 (Calsenilin/DREAM): Expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also acts as a transcriptional regulator by binding to DRE (downstream regulatory elements) and repressing transcription of early-response genes such as c-fos. It is also associated with presenilins and implicated in β-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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