Thermo Fisher Scientific QSER1 Polyclonal Antibody
QSER1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합함. 액상 형태이며 4°C에서 보관. DNA 손상 관련 단백질 연구에 활용 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human glutamine and serine rich 1 (QSER1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
QSER1 (glutamine and serine-rich protein 1) is a 1,735 amino acid protein phosphorylated upon DNA damage, likely by Atm or ATR.
A SNP located between QSER1 and PRRG4 on chromosome 11 (~20 kb apart) has been associated with Parkinson disease.
QSER1 exists as two alternatively spliced isoforms and is conserved across multiple species including chimpanzee, canine, bovine, mouse, rat, chicken, and zebrafish.
It maps to human chromosome 11p13, which contains ~135 million base pairs and ~1,400 genes, representing about 4% of human genomic DNA.
Chromosome 11 is gene- and disease-association dense, with disorders such as Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome linked to defects in this chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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