Thermo Fisher Scientific CLCNKA Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CLCNKA. Recombinant protein control fragment (Product #RP-104514). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLCNKA,uniProtId:P51800-1,ncbiNodeId:9606,antigenRange:525-559,antigenLength:687,antigenImageFileName:PA5-63472_CLCNKA_P51800-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63472_CLCNKA_P51800-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639861

Product Specific Information

Immunogen sequence: IVKKLPYLPR ILGRNIGSHH VRVEHFMNHS ITTLA

Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 74%.

Target Information

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter`s syndrome which is characterized by renal salt-wasting and low blood pressure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.