ELK Biotechnology Ataxin-1 (phospho Ser776) rabbit pAb
Ataxin-1 (phospho Ser776) rabbit polyclonal antibody. Human 및 Mouse 반응성. WB, IHC, IF, ELISA에 사용 가능. 인산화 Ser776 부위 특이적 인식. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
Ataxin-1 (phospho Ser776) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Ataxin 1 around the phosphorylation site of Ser776 (AA range: 742–791) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 87 kD |
| GeneID (Human) | 6310 |
| Human Swiss-Prot No | P54253 |
| Cellular Localization | Cytoplasm, Nucleus. Colocalizes with USP7 in the nucleus. |
| Species Reactivity | Human; Mouse |
Background
Ataxin 1 (ATXN1) is associated with autosomal dominant cerebellar ataxias (ADCA), a group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. ADCA is divided into three groups (types I–III). Type I includes several spinocerebellar ataxia (SCA) subtypes—SCA1, 2, 3, 4, and 6—linked to different chromosomes. Type II (SCA7) presents with retinal degeneration, while type III (SCA5) is a pure cerebellar syndrome. Many SCA genes contain CAG repeat expansions in their coding regions, leading to elongated polyglutamine tracts in the corresponding proteins. These expanded repeats are unstable and tend to increase in size upon transmission, contributing to disease progression.
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