ELK Biotechnology Bcr (phospho Tyr360) rabbit pAb
Bcr (phospho Tyr360) rabbit pAb은 인간 Bcr 단백질의 Tyr360 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며 다양한 종에 반응합니다. 고순도 IgG로 제조되어 신뢰성 높은 신호 검출을 제공합니다.
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제품명
Bcr (phospho Tyr360) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BCR; BCR1; D22S11; Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Bcr around the phosphorylation site of Tyr360. AA range: 331–380 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 142 kDa |
| Gene ID (Human) | 613 |
| Human Swiss-Prot No. | P11274 |
| Cellular Localization | Cell junction, synapse, postsynaptic density, dendritic spine, axon |
| Species Reactivity | Human; Mouse; Monkey |
Background
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein encoded by sequences from both BCR and ABL (the gene at the chromosome 9 breakpoint). Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not fully clear. The protein has serine/threonine kinase activity and functions as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
(Provided by RefSeq, Jul 2008)
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