ELK Biotechnology RPA32 (phospho Thr21) rabbit pAb
RPA32 (phospho Thr21) rabbit pAb는 인간 RPA2 단백질의 Thr21 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며 핵 내 DNA 손상 반응 연구에 적합합니다. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
RPA32 (phospho Thr21) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RPA2; REPA2; RPA32; RPA34; Replication protein A 32 kDa subunit; RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human RFA2 around the phosphorylation site of Thr21 (AA range: 10–59) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 35 kDa |
| GeneID (Human) | 6118 |
| Human Swiss-Prot No | P15927 |
| Cellular Localization | Nucleus, PML body. Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. |
| Species Reactivity | Human; Mouse |
Background
Required for DNA recombination, repair, and replication. RP-A activity is mediated by single-stranded DNA binding and protein interactions.
Phosphorylated in a cell-cycle-dependent manner (from S phase until mitosis) and by ATR upon DNA damage, promoting translocation to nuclear foci.
Can be phosphorylated in vitro by PRKDC/DNA-PK (in presence of Ku and DNA) and by CDC2.
Also present in PML nuclear bodies and redistributes to discrete nuclear foci upon DNA damage.
Forms a heterotrimer of 70, 32, and 14 kDa chains; DNA-binding activity may reside on the 70 kDa subunit.
Interacts with SERTAD3/RBT1 and TIPIN.
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