ELK Biotechnology Rent1 rabbit pAb
Rent1(UPF1) 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 세포질 및 P-body에 주로 위치. -20°C 보관, 고순도 IgG 형태로 제공.
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Rent1 rabbit pAb
제품 개요
Rent1(UPF1) 단백질을 인식하는 토끼 폴리클로날 항체로, mRNA 감시 및 NMD(nonsense-mediated decay) 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rent1 rabbit pAb |
| Alternative Names | UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human UPF1 (AA range: 299–348) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kDa |
| Gene ID (Human) | 5976 |
| Human Swiss-Prot No | Q92900 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, P-body, Nucleus, perinuclear region.
Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
Localized in the chromatoid bodies of round spermatids (By similarity).
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Jul 2014]
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