ELK Biotechnology NFκB-p65 (phospho Ser281) rabbit pAb
NFκB-p65 (phospho Ser281) rabbit pAb는 인산화된 NFκB p65 단백질을 특이적으로 인식하는 폴리클로날 항체입니다. IHC, IF, ELISA에 사용 가능하며 인간, 마우스, 랫트 시료에 반응합니다. 세포 내 NFκB 신호전달 연구에 적합합니다.
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제품명
NFκB-p65 (phospho Ser281) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NF-kappaB p65 around the phosphorylation site of Ser281 (AA range: 247–296) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5970 |
| Human Swiss-Prot No. | Q04206 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm. Found in the cytoplasm in an inactive form complexed to I-kappa-B (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L. monocytogenes infection (PubMed:20855622). |
Background
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
[Provided by RefSeq, Sep 2011]
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