ELK Biotechnology p107 (phospho Thr369) rabbit pAb
인간 RBL1의 Thr369 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 세포주기 조절 및 종양억제 관련 연구에 적합. 고순도 IgG, 농도 1 mg/ml, -20°C에서 1년 보관.
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p107 (phospho Thr369) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RBL1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369 (AA range: 335–384) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5933 |
| Human Swiss-Prot No | P28749 |
| Cellular Localization | Nucleus |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein involved in cell cycle regulation, being phosphorylated during the S to M phase transition and dephosphorylated in the G1 phase. Both RB1 and RBL1 proteins form complexes with adenovirus E1A and SV40 large T-antigen, with the latter binding only to the unphosphorylated forms. These proteins can inhibit transcription of cell cycle genes containing E2F binding sites, suggesting that RBL1 may also act as a tumor suppressor. Two transcript variants encoding different isoforms have been identified.
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