ELK Biotechnology Raf-1 (phospho Tyr341) rabbit pAb
Raf-1 단백질의 Tyr341 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포 내 RAF1 신호전달 연구에 유용하며, 사람, 생쥐, 랫트에 반응합니다. -20°C에서 1년 보관 가능합니다.
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- ES6980-xxxxx (2개 옵션)
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제품명
Raf-1 (phospho Tyr341) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C-RAF around the phosphorylation site of Tyr341 (AA range: 311-360) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 73 kD |
| Gene ID (Human) | 5894 |
| Human Swiss-Prot No. | P04049 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Cell membrane, Mitochondrion, Nucleus. Colocalizes with RGS14 and BRAF in both cytoplasm and membranes. Phosphorylation at Ser-259 impairs membrane accumulation. Recruited to the cell membrane by active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for mitochondrial localization. Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus. |
Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane-associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine-specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
[provided by RefSeq, Jul 2008]
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