ELK Biotechnology Raf-1 (phospho Ser642) rabbit pAb
Raf-1 (phospho Ser642) rabbit polyclonal antibody로, 인간, 마우스, 랫트에 반응합니다. WB, ELISA, IHC에 적합하며, 세포 내 Raf-1 단백질의 인산화 상태 분석에 사용됩니다. 고순도 IgG, -20°C에서 1년 보관 가능합니다.
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- ES6979-xxxxx (2개 옵션)
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제품명
Raf-1 (phospho Ser642) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against a synthesized peptide derived from human C-RAF around the phosphorylation site of Ser642. (AA range: 599–648) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kDa |
| Gene ID (Human) | 5894 |
| Human Swiss-Prot No. | P04049 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, Cell membrane, Mitochondrion, Nucleus.
Colocalizes with RGS14 and BRAF in both cytoplasm and membranes.
Phosphorylation at Ser-259 impairs membrane accumulation.
Recruited to the cell membrane by active Ras protein.
Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for mitochondrial localization.
Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized in the nucleus.
Background
This gene is the cellular homolog of the viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), functioning downstream of Ras family GTPases. Activated RAF1 phosphorylates and activates MEK1/2, which in turn activate ERK1/2. These kinases regulate gene expression related to cell cycle, apoptosis, differentiation, and migration.
Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
[Provided by RefSeq, Jul 2008]
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