ELK Biotechnology Raf-1 (phospho Ser301) rabbit pAb
Raf-1 (phospho Ser301) rabbit pAb는 인산화 Raf-1 단백질(Ser301)을 특이적으로 인식하는 폴리클로날 항체입니다. WB, ELISA, IHC에 사용 가능하며, 인간, 생쥐, 랫트 시료에 반응합니다. 세포 내 신호전달 연구 및 Raf-1 인산화 상태 분석에 적합합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Raf-1 (phospho Ser301) rabbit pAb
Raf-1 (phospho Ser301) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Raf-1 (phospho Ser301) rabbit pAb |
| Alternative Names | RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Raf-1 (phospho Ser301) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kD |
| Gene ID (Human) | 5894 |
| Human Swiss-Prot No | P04049 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cell membrane, mitochondrion, nucleus.
Colocalizes with RGS14 and BRAF in both cytoplasm and membranes.
Phosphorylation at Ser-259 impairs membrane accumulation.
Recruited to the cell membrane by active Ras protein.
Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for mitochondrial localization.
Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus.
Background
This gene is the cellular homolog of the viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K) functioning downstream of the Ras family of membrane-associated GTPases. Once activated, RAF1 phosphorylates and activates the dual specificity protein kinases MEK1 and MEK2, which in turn activate ERK1 and ERK2. Activated ERKs regulate gene expression related to cell division, apoptosis, differentiation, and migration.
Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
(Provided by RefSeq, Jul 2008)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.