ELK Biotechnology Peroxin 19 rabbit pAb
Peroxin 19(PEX19) 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포질 및 퍼옥시솜 막에 위치한 단백질 검출에 적합. -20°C에서 1년 보관.
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제품명
Peroxin 19 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PEX19; HK33; PXF; OK/SW-cl.22; Peroxisomal biogenesis factor 19; 33 kDa housekeeping protein; Peroxin-19; Peroxisomal farnesylated protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PEX19 (AA range: 219–268) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kD |
| Gene ID (Human) | 5824 |
| Human Swiss-Prot No. | P40855 |
| Cellular Localization | Cytoplasm; Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Mainly cytoplasmic, with some fraction membrane-associated to the outer surface of peroxisomes. |
| Species Reactivity | Human; Rat; Mouse |
Background
Peroxisomal biogenesis factor 19 (PEX19) is essential for early peroxisomal biogenesis. It functions as a cytosolic chaperone and import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are required for the assembly of functional peroxisomes. Peroxisome biogenesis disorders (PBDs) are genetically heterogeneous autosomal recessive diseases characterized by multiple defects in peroxisome function. These disorders include at least 14 complementation groups, with varying phenotypes. Defects in the PEX19 gene are associated with Zellweger syndrome (ZWS) and peroxisome biogenesis disorder complementation group 14 (PBD-CG14).
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