ELK Biotechnology PTP IA-2β rabbit pAb
PTP IA-2β 단백질에 특이적인 토끼 다클론 항체로, WB, ELISA, IHC에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 세포 내 분비 소포막 단백질 연구에 활용됩니다. 인슐린 분비 조절 관련 연구에 유용합니다.
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ELK Biotechnology PTP IA-2β rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PTP IA-2β rabbit pAb |
| Alternative Names | PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PTPRN2. AA range: 206–255 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 111 kDa |
| Gene ID (Human) | 5799 |
| Human Swiss-Prot No. | Q92932 |
| Cellular Localization | Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Predominantly found on dense-core secretory granules. Sorting to secretory granules depends in part on the N-terminal propeptide domain and its interaction with CPE (By similarity). Transiently found at the cell membrane during vesicle fusion, then endocytosed and recycled to secretory vesicles via clathrin-dependent AP2-mediated endocytosis and STX6-containing compartments (By similarity). [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase capable of dephosphorylating phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, potentially involved in insulin secretion regulation. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. (RefSeq, Feb 2015)
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