ELK Biotechnology FAK (phospho Tyr576) rabbit pAb
FAK (phospho Tyr576) rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로 WB, IHC, IF, ELISA에 적합합니다. Tyr576 인산화 부위에서 유래한 펩타이드로 면역생성되었으며, 세포 부착 및 신호전달 연구에 유용합니다.
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FAK (phospho Tyr576) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FAK (phospho Tyr576) rabbit pAb |
| Alternative Names | PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FAK around the phosphorylation site of Tyr576 (AA range: 542-591) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 119 kD |
| Gene ID (Human) | 5747 |
| Human Swiss-Prot No. | Q05397 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell junction, focal adhesion; Cell membrane (peripheral membrane protein, cytoplasmic side); Cytoplasm (cell cortex, cytoskeleton, microtubule organizing center, centrosome, cilium basal body); Nucleus; Constituent of focal adhesions; Detected at microtubules |
Background
Protein tyrosine kinase 2 (PTK2) Homo sapiens
This gene encodes a cytoplasmic protein tyrosine kinase concentrated in focal adhesions formed between cells and extracellular matrix components. The encoded protein belongs to the FAK subfamily of protein tyrosine kinases and is distinct from other subfamilies. Activation of PTK2 is an early step in cell growth and intracellular signal transduction pathways triggered by neural peptides or cell-extracellular matrix interactions. Several transcript variants encoding different isoforms have been identified, with four full-length forms determined.
[Provided by RefSeq, Oct 2015]
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