ELK Biotechnology Trk C (phospho Tyr516) rabbit pAb
Trk C (phospho Tyr516) rabbit pAb는 인간, 마우스, 랫트 시료에서 TrkC 인산화 단백질을 검출하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며, 고순도 IgG로 1 mg/ml 농도로 제공됩니다. Tyr516 인산화 부위 특이적 인식으로 신경세포 분화 연구에 유용합니다.
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제품명
Trk C (phospho Tyr516) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NTRK3; TRKC; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516 (AA range: 482–531) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160 kDa |
| GeneID (Human) | 4916 |
| Human Swiss-Prot No. | Q16288 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas, and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
[Provided by RefSeq, Jul 2011]
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