ELK Biotechnology PAF-R rabbit pAb
PAF-R rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 다클론 항체로, 세포막에 위치한 PAF 수용체를 인식합니다. IF와 ELISA에 적합하며, 암 및 염증 연구에 활용됩니다. 합성 펩타이드 면역원으로 제작되었으며, -20°C에서 1년 보관 가능합니다.
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제품명
PAF-R rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr |
| Applications | IF; ELISA |
| Recommended Dilutions | Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PTAFR (AA range: 194-243) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5724 |
| Human Swiss-Prot No. | P25105 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane.
PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes.
Binding of PAF to the PAF receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system.
Following PAFR activation, cells become rapidly desensitized, and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation.
Alternative splicing results in multiple transcript variants.
[Provided by RefSeq, Aug 2011]
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