ELK Biotechnology 20S Proteasome α3 (phospho Ser250) rabbit pAb
20S Proteasome α3의 Ser250 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며, 인간, 생쥐, 랫트 반응성. 세포질 및 핵 내 위치 검출에 유용. 고순도 IgG, 1 mg/ml 농도.
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제품명
20S Proteasome α3 (phospho Ser250) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
20S Proteasome α3 단백질의 Ser250 인산화 부위를 인식하는 rabbit polyclonal antibody로, 다양한 면역학적 분석(WB, IHC, IF, ELISA)에 사용됩니다. 인간, 생쥐, 랫트에서 반응성이 확인되었습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Alternative Names | PSMA3; HC8; PSC8; Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human Proteasome α3 around the phosphorylation site of Ser250 (AA range: 206–255) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 32 kDa |
| GeneID (Human) | 5684 |
| Human Swiss-Prot No. | P25788 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm and nucleus. Translocated from cytoplasm into nucleus following interaction with AKIRIN2, bridging proteasome and nuclear import receptor IPO9. |
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. This core is composed of four rings of 28 non-identical subunits — two rings of seven alpha subunits and two rings of seven beta subunits. Proteasomes are abundant in eukaryotic cells and function in ATP/ubiquitin-dependent peptide cleavage through a non-lysosomal pathway. The immunoproteasome variant plays an essential role in processing class I MHC peptides. This gene encodes a member of the peptidase T1A family and represents a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. (RefSeq, Jul 2008)
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