ELK Biotechnology TOK-1 rabbit pAb
TOK-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. BRCA2 및 p21과 상호작용하는 핵 단백질 연구에 적합. 인체, 생쥐, 랫트 시료에서 반응. 고순도 IgG, 1 mg/ml 농도.
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제품명
TOK-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BCCIP; TOK1; BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; Protein TOK-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from TOK-1 (AA range: 60–140) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 35 kDa |
| Gene ID (Human) | 56647 |
| Human Swiss-Prot No. | Q9P287 |
| Cellular Localization | Nucleus; Cytoplasm; Cytoskeleton; Microtubule organizing center; Centrosome; Centriole; Spindle pole. Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferentially localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). Isoform 1: Less abundant and weakly associated with centrosomes. Isoform 2: More abundant and strongly associated with centrosomes. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene product was identified based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting calcium-binding potential. Functional studies indicate that this protein may act as a cofactor for BRCA2 in tumor suppression and modulate CDK2 kinase activity via p21. It is also implicated in BRCA2 and RAD51 nuclear focus formation, homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described (RefSeq, Jul 2008).
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