ELK Biotechnology MEK-2 rabbit pAb
MEK-2 rabbit pAb는 인간 MAP2K2 유래 펩타이드로부터 제작된 폴리클로날 항체로, WB, IHC, IF, IP, ELISA 등 다양한 응용에 적합합니다. 세포 내 MAPK/ERK 경로 연구에 활용되며, 인간, 마우스, 랫트에 반응합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
MEK-2 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunoprecipitation: 2-5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MAP2K2 (AA range: 261–310) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| GeneID (Human) | 5605 |
| Human Swiss-Prot No | P36507 |
| Cellular Localization | Cytoplasm; Membrane; Peripheral membrane protein. Membrane localization is probably regulated by its interaction with KSR1. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. It plays a critical role in mitogen growth factor signal transduction by phosphorylating and activating MAPK1/ERK2 and MAPK2/ERK3. Activation of this kinase depends on Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), characterized by heart defects, mental retardation, and distinctive facial features similar to Noonan syndrome. Inhibition or degradation of this kinase is involved in the pathogenesis of Yersinia and anthrax. A pseudogene located on chromosome 7 has been identified for this gene. (Provided by RefSeq, Jul 2008)
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