ELK Biotechnology MEK-1 (phospho Thr292) rabbit pAb
MEK-1 (phospho Thr292) rabbit polyclonal antibody로, MAPK/ERK 신호전달 경로 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용 가능하며, 인간·생쥐·랫트 반응성 확인됨. 세포 내 MEK1 인산화 상태 분석에 유용합니다.
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MEK-1 (phospho Thr292) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | MEK-1 (phospho Thr292) rabbit pAb |
| Alternative Names | MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MEK1 around the phosphorylation site of Thr291 (AA range: 261–310) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kD |
| GeneID (Human) | 5604 |
| Human Swiss-Prot No | Q02750 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Cytoplasm, nucleus, membrane; peripheral membrane protein.
Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111).
Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742).
Background
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates their enzymatic activity upon a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. [provided by RefSeq, Jul 2008]
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