ELK Biotechnology PKAα cat (phospho Ser338) rabbit pAb

제품명

PKAα cat (phospho Ser338) rabbit pAb

대체 명칭

PRKACA, PKACA, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha

응용 분야

• IHC
• IF
• ELISA

권장 희석 배율

면역원

Synthesized phospho-peptide around the phosphorylation site of human PKAα cat (phospho Ser338)

저장 및 안정성

• 종: Rabbit
• 저장 조건: -20°C, 1년 안정

항체 정보

유전자 정보

세포 내 위치

Cytoplasm, Cell membrane, Nucleus, Mitochondrion, Membrane (Lipid-anchor).
Translocates into the nucleus as a monomeric catalytic subunit.
Inactive holoenzyme is found in the cytoplasm.
Distributed throughout cytoplasm in meiotically incompetent oocytes.
Associated with mitochondria during meiotic competence acquisition.
Aggregates around germinal vesicles in immature GV-stage oocytes.
Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:21085490).
Isoform 2: Found in cilium, flagellum, secretory vesicle, and acrosome.
Expressed in midpiece of sperm flagellum (PubMed:10906071).
Colocalizes with MROH2B and TCP11 in acrosome and tail regions of spermatids and spermatozoa.

배경 정보

This gene encodes one of the catalytic subunits of protein kinase A (PKA).
The inactive form exists as a tetrameric holoenzyme with two regulatory and two catalytic subunits.
cAMP binding induces dissociation into regulatory dimers and free catalytic monomers.
PKA-mediated phosphorylation regulates key cellular processes such as differentiation, proliferation, and apoptosis.
Constitutive activation due to mutations or duplications involving this gene is associated with adrenal cortex hyperplasias and corticotropin-independent Cushing’s syndrome.

반응 종

Human, Mouse, Rat