ELK Biotechnology AMPKβ1 rabbit pAb
AMPKβ1 단백질에 특이적인 rabbit polyclonal antibody로, WB, IHC, IF, ELISA 등 다양한 응용에 적합합니다. 인간 PRKAB1 유래 합성 펩타이드로 면역된 항체이며, 세포 내 에너지 대사 연구에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
AMPKβ1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PRKAB1 (AA range: 10–59) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| Gene ID (Human) | 5564 |
| Human Swiss-Prot No | Q9Y478 |
| Cellular Localization | nucleus, nucleoplasm, cytosol, nucleotide-activated protein kinase complex |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. It is a key energy-sensing enzyme that monitors cellular energy status. Under metabolic stress, AMPK becomes activated and phosphorylates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), enzymes that regulate fatty acid and cholesterol biosynthesis. The beta-1 subunit may positively regulate AMPK activity and influence its localization via myristoylation and phosphorylation. It also serves as an adaptor molecule mediating AMPK complex assembly.
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