ELK Biotechnology TRAP220 (phospho Thr1457) rabbit pAb
TRAP220 (phospho Thr1457) rabbit polyclonal antibody로, 인산화 Thr1457 부위에 특이적입니다. WB, IHC, IF, ELISA에 사용 가능하며 핵 내 단백질 검출에 적합합니다. 인간, 마우스, 원숭이에 반응하며 1 mg/ml 농도로 제공됩니다.
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ELK Biotechnology TRAP220 (phospho Thr1457) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TRAP220 (phospho Thr1457) rabbit pAb |
| Alternative Names | MED1; ARC205; CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2; Mediator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Peroxiso |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPAR-BP around the phosphorylation site of Thr1457. AA range: 1423–1472 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 168 kD |
| Gene ID (Human) | 5469 |
| Human Swiss-Prot No | Q15648 |
| Cellular Localization | Nucleus. A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. |
| Species Reactivity | Human; Mouse; Monkey |
Background
The activation of gene transcription is a multistep process triggered by factors recognizing transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus.
The encoded protein is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.
It is also a component of other multisubunit complexes, such as thyroid hormone receptor-associated proteins (TRAPs), which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Additionally, it regulates p53-dependent apoptosis and is essential for adipogenesis. The protein is known to self-oligomerize.
[provided by RefSeq, Jul 2008]
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