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ELK Biotechnology RIAM rabbit pAb
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RIAM 단백질을 인식하는 토끼 폴리클로날 항체로 WB 및 IHC에 적합. 세포막 및 세포골격 관련 단백질 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES6660-100UL RIAM rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES6660-50UL RIAM rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology RIAM rabbit pAb
ELK Biotechnology RIAM rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RIAM rabbit pAb |
| Alternative Names | APBB1IP; PREL1; RARP1; RIAM; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; Proline-rich EVH1 ligand 1; PREL-1; Proline-rich protein 73; Rap1-GTP-interacting adapter molecule |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from RIAM (AA range: 430–510) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 73 kDa |
| Gene ID (Human) | 54518 |
| Human Swiss-Prot No. | Q7Z5R6 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Peripheral membrane protein; Cell projection (lamellipodium); Cell junction (focal adhesion); Cytoplasm (cytoskeleton).
Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and with F-actin at the leading edge.
At the membrane surface, associates via the PH domain preferentially with inositol phosphates PtdIns(5)P and PtdIns(3)P.
This binding is necessary for efficient interaction of the RA domain with Ras-GTPases (By similarity).
Background
- Domain: Two Pro-rich regions are required for suppression of AP1 transcription activity.
- Function: Functions in signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
- Induction: Induced by all-trans-retinoic acid.
- Similarity: Belongs to the MRL family; contains 1 PH domain and 1 Ras-associating domain.
- Subcellular location: Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and with F-actin at the leading edge. Associates via PH domain with PtdIns(5)P and PtdIns(3)P for Ras-GTPase interaction.
- Subunit: Interacts through the N-terminal Pro-rich region with the WW domain of APBB1. Also interacts with RAP1A, PFN1, VASP, and ENAH.
- Tissue specificity: Widely expressed, with high expression in thymus, spleen, lymph node, bone marrow, and peripheral leukocytes.
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