ELK Biotechnology ATP7B rabbit pAb
ATP7B 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 적합합니다. 인간 유래 펩타이드 항원으로 제작되었으며, 구리 수송 관련 단백질 연구에 유용합니다. -20°C에서 1년 보관 가능하며, 인간, 마우스, 랫트에 반응합니다.
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제품명
ATP7B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATP7B; PWD; WC1; WND; Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATP7B (AA range: 161–210) |
| Host Species | Rabbit |
| Storage Conditions | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 540 |
| Human Swiss-Prot No. | P35670 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Golgi apparatus, trans-Golgi network membrane, multi-pass membrane protein, late endosome.
Predominantly found in the trans-Golgi network (TGN).
Localized in the trans-Golgi network under low copper conditions and redistributes to cytoplasmic vesicles under elevated copper levels, returning to the TGN when copper is removed (PubMed:10942420).
- Isoform 1: Golgi apparatus membrane (multi-pass membrane protein)
- Isoform 2: Cytoplasm
- WND/140 kDa: Mitochondrion
배경 (Background)
This gene belongs to the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two copper-binding sites.
The protein functions as a monomer, exporting copper out of cells, such as hepatic copper efflux into bile.
Alternative splice variants encode isoforms with distinct cellular localizations.
Mutations in this gene are associated with Wilson disease (WD).
(RefSeq, Jul 2008)
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