ELK Biotechnology uPA rabbit pAb
Human uPA 단백질을 인식하는 rabbit polyclonal antibody로, IHC·IF·ELISA에 적합합니다. 합성 human uPA peptide(AA 190–239)를 면역원으로 제작되었으며, 고순도 IgG 형태(1 mg/ml)로 제공됩니다. Human, Rat, Mouse 반응성이 확인되었습니다.
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제품명
uPA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PLAU; Urokinase-type plasminogen activator; U-plasminogen activator; uPA |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human uPA (AA range: 190–239) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5328 |
| Human Swiss-Prot No | P00749 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer’s disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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